Hyperactivation and aggregation of platelets play a major role in thrombosis and hemostasis. The aims of this study were to investigate the effects of omega-3 polyunsaturated fatty acids (PUFAs) on platelet function. Light transmission aggregometry and flow cytometric analyses of platelet activation and platelet-leukocyte aggregates were determined at baseline and after 4 weeks of omega-3 (docosahexaenoic acid 520 mg and eicosapentaenoic acid 120 mg) supplementation.
In total, 40 healthy subjects and 16 patients with a history of cardiovascular disease (CVD) completed the study. In healthy subjects, omega-3 PUFA significantly reduced adenosine diphosphate (ADP)-induced (maximum amplitude, 77.0% ± 3.2% vs. 71.6% ± 3.4%, p = 0.036; maximum slope, 86.3 ± 1.8 vs. 80.7 ± 2.1, p = 0.014) and adrenaline-induced platelet aggregation (maximum slope, 42.8 ± 2.7 vs. 37.4 ± 3.0, p = 0.013; lag time, 00:21 ± 00:02 vs. 00:31 ± 00:03 s, p = 0.002). Omega-3 PUFA also reduced P-selectin expression (40.5% ± 2.9% vs. 34.4% ± 2.4%, p = 0.049) on platelets and platelet-monocyte aggregates (38.5% ± 2.6% vs. 31.4% ± 2.5%, p = 0.022) after activation with ADP 0.5 µM. There were fewer changes in platelet aggregation and activation found in subjects with CVD. Nevertheless, there was a reduction in the slope of arachidonic acid-induced platelet aggregation (13.21 ± 6.41 vs. 4.88 ± 3.01, p = 0.009) and increased lag time for U46619 (00:16 ± 00:00 vs. 00:29 ± 00:07 s, p = 0.018) induced platelet aggregation.
Thus, 4-week supplementation of 640 mg omega-3 PUFA reduced measures of platelet aggregation and activation in healthy subjects but effects were less evident in patients with existing CVD. Our findings support the recommendation that the omega-3 PUFA dose be higher in CVD than among healthy subjects.
McEwen BJ, Morel-Kopp MC, Chen W, Tofler GH, Ward CM. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. Semin Thromb Hemost. 2013 Feb;39(1):25-32. (http://www.ncbi.nlm.nih.gov/pubmed/23329646)
Pyrrole disorder can be described as a complex disorder. The causes of pyrrole disorder are not completely understood. There has been an influx of people with potential pyrrole disorder in clinic in the last year or so, especially since the website post last year.
All humans excrete small quantities of hydroxyhemopyrrolin-2’one (HPL) in urine. The level of HPL is tested via a urine test. The level of HPL increases with physical or emotional stress. Elevated HPL has been observed in people with depression. Some laboratories have set the normal concentration of HPL in urine as less than 25 μg/dL. However, practitioners may associate HPL levels twice that amount as being elevated.
The signs and symptoms of pyrrole disorder are similar to that of vitamin B6 and zinc deficiency. The HPL molecule can bind up zinc and vitamin B6 and excrete them, leading to a deficiency.
Hopefully research will provide more information about Pyrrole Disorder the next few years. One of my aims is to conduct clinical trials investigating the levels of HPL and mental health, especially in depression and anxiety, and cardiometabolic disease.
Pyrrole disorder can be described as a complex disorder. The causes of pyrrole disorder are not completely understood.
All humans excrete small quantities of hydroxyhemopyrrolin-2’one (HPL) in urine. The level of HPL increases with physical or emotional stress. Some laboratories have set the normal concentration of HPL in urine as 2 to 25 μg/dL. However, practitioners may associate HPL levels twice that amount as being elevated.
The signs and symptoms of pyrrole disorder are similar to that of vitamin B6 and zinc deficiency.
Hopefully research will provide more information about Pyrrole Disorder the next few years.
Diabetes and cardiovascular disease are major public health concerns worldwide and are leading causes of morbidity and mortality. People with type 2 diabetes are at an increased risk for cardiovascular disease. Diet has a substantial affect on the progression of many diseases, including diabetes, cardiovascular disease, osteoporosis, and arthritis. Omega-3 polyunsaturated fatty acids (long-chain polyunsaturated fatty acids [LC-PUFA]) have long been attributed to the maintenance of health and may be of benefit in reducing cardiovascular risk. The purpose of this review is to investigate the possible roles of omega-3 in reducing cardiovascular risk in patients with diabetes.
A literature search was conducted from the Medline, EBSCO, and EMBASE databases. Articles that addressed diabetes, cardiovascular disease, or omega-3 were included.
Reviews and studies reported an association with fish and omega-3 LC-PUFA consumption and decreased total cardiovascular mortality (approximately 15%-19%), along with decreased platelet activation and aggregation, improved lipid profiles, including reduction of triglycerides and very low-density lipoprotein (VLDL), decreased inflammation, and lowered blood pressure.
Diets higher in fish and omega-3 LC-PUFA may reduce cardiovascular risk in diabetes by inhibiting platelet aggregation, improving lipid profiles, and reducing cardiovascular mortality. Fish and omega-3 LC-PUFA can be recommended to people with diabetes and included into a diabetes management program.
McEwen B, Morel-Kopp MC, Tofler G, Ward C. Effect of omega-3 fish oil on cardiovascular risk in diabetes. Diabetes Educ. 2010 Jul-Aug;36(4):565-84. (http://www.ncbi.nlm.nih.gov/pubmed/20534874)
I’ve always seen food as medicine and herbal teas play a very big role in supporting and improving health. I have used herbal teas and combinations of loose herbal teas in my clinic for many years. During high school I did a subject in business that allowed me to work under a herbalist in a health food store. This experience brought forward my love of herbal teas.
I’ve just started a PhD at the University of Sydney. I will be researching the effects of fish oil (omega-3) in cardiovascular disease. It’s going to be a lot of work, but I’m really looking forward to it. Food as medicine 🙂 .
I am currently creating a herbal tea brand that will be available in the future. I am going to try to have the herbal teas certified organic. I’m very excited about this. A dream coming true. Stay tuned…