Saffron, PMS, and Mood

I love Saffron. It has many uses, including for mood. Saffron has antidepressant, anti-anxiety, anti-inflammatory, antioxidant, radical scavenger effects, neuroprotective, neuro-endocrine, learning, and memory improving effects.

A study investigated the effect of stigma of Saffron on relieving the symptoms of premenstrual syndrome (PMS) on 20-45 aged women with; regular menstrual cycles and the experience of the symptoms of PMS for at least 6 months. They received either 30 mg per day saffron or placebo. PMS symptoms were evaluated using a Premenstrual Daily Symptoms (PDS) questionnaire and Hamilton Depression Rating Scale (HAM-D). There was a significant difference in the efficacy of saffron in the Total PDS and HAM-D. The results indicated the positive effect of Saffron in alleviation of PMS symptoms. Another study showed that Saffron 30 mg/day (15 mg twice a day) for 2 menstrual cycles could reduce the depression score as well as the menstruation symptoms.


Lopresti AL, Drummon PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. 2014 Nov; 29(6): 517-27.

Moshiri M et al. Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review. Drug Res (Stuttg). 2015 Jun; 65(6): 287-95.

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