Passionflower (Passiflora incarnata) is one of my most favourite herbs. Have used it with patients since day 1. I tend to combine it with Ashwagandha (Withania), Chamomile, Lemon Balm, Rehmannia, Rhodiola, Inositol, and Vitamin C.
A double-blind randomised trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial.
Passiflora extract and oxazepam were effective in the treatment of generalised anxiety disorder. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. The results suggest that Passiflora extract is effective for the management of generalised anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage.
Reference: Akhondzadeh S et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct; 26(5): 363-7.